MEDSynth's significant publications
2023
2022
2021
2020
Bonanni, D., Lolli, M.L., Bajorath, J. Computational Method for Structure-Based Analysis of SAR Transfer. Journal of Medicinal Chemistry. 2020, 63(3), 1388-1396 https://doi.org/10.1021/acs.jmedchem.9b01931
2019
Lolli, M.L., Carnovale, I.M., Pippione, A.C., Wahlgren, W.Y., Bonanni, D., Marini, E., Zonari, D., Gallicchio, M., Boscaro, V., Goyal, P., Friemann, R., Rolando, B., Bagnati, R., Adinolfi, S., Oliaro-Bosso, S., Boschi, D.Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3 . ACS MED. CHEM. LETT. 2019, 10 (4), 437-443 https://doi.org/10.1021/acsmedchemlett.8b00484
2018
Giraudo, A. Krall, J., Nielsen, B., Sørensen, T.E., Kongstad, K.T., Rolando, B., Boschi, D, Frølund, B.* and Lolli, M.L. * 4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric γ-aminobutyric acid receptor binding site. Eu. J. Medicinal Chemistry, 2018, 158, 311-321 https://doi.org/10.1016/j.ejmech.2018.08.094
Grossert, J.S., Boschi, D., Lolli, M.L., White, R.L. Fragmentation pathways arising from protonation at different sites in aminoalkyl-substituted 3-hydroxy-1,2,5-oxadiazoles (3-hydroxyfurazans). Rapid Communications in Mass Spectrometry, 2018, 32(16),1403-1413. https://doi.org/10.1002/rcm.8166
Sainas, S., Pippione, A.C., Boschi, D., Gaidano, V., Circosta, P., Cignetti, A., Dosio, F., Lolli, M.L. DHODH inhibitors and leukemia: An emergent interest for new myeloid differentiation agents. Drugs of the Future, 2018, 43 (11), 823-834 DOI: 10.1358/dof.2018.043.11.2856492
Marco L. Lolli, Stefano Sainas, Agnese C. Pippione, Marta Giorgis, Donatella Boschi and Franco Dosio* Use of human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors in Autoimmune Diseases and New Perspectives in Cancer Therapy. Recent Patents on Anti-Cancer Drug Discovery 2018, 13(1), 218. DOI:10.2174/1574892812666171108124218
Sainas, S., Dosio, F., Boschi, D., Lolli, M.L.* Targeting Human Onchocerciasis: Recent Advances Beyond Ivermectin. Annual Reports in Medicinal Chemistry, 2018, 51, 1-38 https://doi.org/10.1016/bs.armc.2018.08.001
Sanchez, Elena; Artuso, Emma; Lombardi, Chiara; Visentin, Ivan; Lace, Beatrice; Saeed, Wajeeha; Lolli, Marco L.; Kobauri, Piermichele; Ali, Zahid; Spyrakis, Francesca; Cubas, Pilar; Cardinale, Francesca; Prandi, Cristina New insights into Structure Activity Relationship of strigolactones via a novel, quantitative in planta bioassay. J. Exp. Botany, 2018, 69(9), pp. 2333-2343 https://doi.org/10.1093/jxb/ery092
Pippione, Agnese Chiara, Carnovale, Irene Maria, Bonanni, Davide, Sini, Marcella, Goyal, Parveen, Marini, Elisabetta, Pors, Klaus, Adinolfi, Salvatore, Zonari, Daniele, Festuccia, Claudio, Wahlgren, Weixiao Yuan, Friemann, Rosmarie, Bagnati, Renzo, Boschi, Donatella, Oliaro-Bosso, Simonetta, * and Lolli, Marco Lucio* Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: Application of a bioisosteric scaffold hopping approach to flufenamic acid. Eu. J. Medicinal Chemistry, 2018, 150, 930-945 https://doi.org/10.1016/j.ejmech.2018.03.040
Irene Maria Carnovale, Marco Lucio Lolli, Sonia Colombo Serra, Alberto Fringuello Mingo, Roberta Napolitano, Valeria Boi, Nicol Guidolin, Luciano Lattuada, Fabio Tedoldi, Zsolt Baranyai* and Silvio Aime* Exploring the intramolecular catalysis of the proton exchange process to modulate the relaxivity of Gd(III)-complexes of HP-DO3A-like ligands. Chem Comm, 2018, 54, 72, 2018, 10056-10059 https://doi.org/10.1039/C8CC05284K
Sainas, Stefano; Pippione, Agnese; Lupino, Elisa; Giorgis, Marta; Circosta, Paola; Gaidano, Valentina; Goyal, Parveen; Bonanni, Davide; Rolando, Barbara; Cignetti, Alessandro; Ducime, Alex; Andersson, Mikael; Järvå, Michael; Friemann, Rosmarie; Piccinini, Marco; Ramondetti, Cristina; Buccinnà, Barbara; Al-Karadaghi, Salam; Boschi, Donatella; Saglio, Giuseppe; Lolli, Marco* Targeting myeloid differentiation using potent 2-hydroxypyrazolo[1,5-a]pyridine scaffold-based human dihydroorotate dehydrogenase (hDHODH) inhibitors. J. Medicinal Chemistry, 2018, 61 (14), 6034-6055. https://doi.org/10.1021/acs.jmedchem.8b00373
2017
Pippione, A. C.; Boschi, D.; Pors, K.; Oliaro-Bosso, S.; Lolli, M. L. Androgen-AR axis in primary and metastatic prostate cancer: chasing steroidogenic enzymes for therapeutic intervention. Journal of Cancer Metastasis and Treatment, 2017, 3, 328-61 DOI:10.20517/2394-4722.2017.44
Agnese C. Pippione, Antonella Federico, Alex Ducime, Stefano Sainas, Donatella Boschi, Alessandro Barge, Elisa Lupino, Marco Piccinini, Michael Kubbutat, Jean-Marie Contreras, Christophe Morice, Salam Al-Karadaghi and Marco L. Lolli.* 4-Hydroxy-N-[3,5-bis(trifluoromethyl)phenyl]- 1,2,5-thiadiazole-3-carboxamide: a novel inhibitor of the canonical NF-kB cascade. Med. Chem. Commun., 2017, 8, 1850-1855 https://doi.org/10.1039/C7MD00278E
Elena Campaner*, Alessandra Rustighi*, Alessandro Zannini, Alberto Cristiani, Silvano Piazza, Yari Ciani, Ori Kalid, Gali Golan, Erkan Baloglu, Sharon Shacham, Barbara Valsasina, Ulisse Cucchi, Agnese Chiara Pippione, Marco Lucio Lolli, Barbara Giabbai, Paola Storici, Paolo Carloni, Giulia Rossetti, Federica Benvenuti, Ezia Bello, Maurizio D’Incalci, Elisa Cappuzzello, Antonio Rosato & Giannino Del Sal. A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action . Nature Communications, 2017, (8), 15772. https://doi.org/10.1038/ncomms15772
Sainas Stefano, Pippione Agnese C., Giorgis Marta, Lupino Elisa, Goyal Parveen, Ramondetti Cristina, Buccinnˆ Barbara, Piccinini Marco, Braga Rodolpho C., Andrade Carolina H., Andersson Mikael, Moritzer Ann-Christin, Friemann Rosmarie, Mensa Stefano, Al-Karadaghi Salam, Boschi Donatella, Lolli Marco L. Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds. Eur. J. Med. Chem. 2017, 129, 287-302, doi: 10.1016/j.ejmech.2017.02.017
Chiara Lombardi, Emma Artuso, Eleonora Grandi, Marco Lolli, Francesca Spirakys, Emanuele Priola, and Cristina Prandi Synthesis of Analogues of Phytohormones Strigolactones with Ring-Closing Metathesis as a Key Step. Org. Biomol. Chem. 2017, 15, 8218-8231https://doi.org/10.1039/C7OB01917C
2015
J. Stuart Grossert, Agnese C. Pippione, Donatella Boschi, Marco L. Lolli, Robert L. White. Heterocyclic ring cleavage upon collision-induced dissociation of deprotonated 3-hydroxy-1,2,5-oxadiazoles (3-hydroxyfurazans). Journal of Mass Spectrometry. 2015, 50, p. 1433-1437, ISSN: 1096-9888, https://doi.org/10.1002/jms.3724
Marco Lolli, Sarah Narramore, Colin W.G. Fishwick and Klaus Pors. Refining the chemical toolbox for drug discovery in the 21st Century. Drug Discovery of Today 2015, 20(8), 1018 - 1026. https://doi.org/10.1016/j.drudis.2015.04.010
Cristian Taccioli, Giovanni Sorrentino, Alessandro Zannini, Jimmy Caroli, Domenico Beneventano, Laura Anderlucci, Naomi Ruggeri, Marco Lolli, Silvio Bicciato and Giannino Del Sal. MDP, a database linking drug response data to genomic information, identifies Dasatinib and Statins as a combinatorial strategy to inhibit YAP/TAZ in cancer cells. Oncotarget 2015, 10, 6(36), 38854 doi: 10.1007/s00894-012-1643-5
Other representative publications
Silvia Bonomo, Paolo Tosco, Marta Giorgis, Marco Lolli, Roberta Fruttero The role of fluorine in stabilizing the bioactive conformation of dihydroorotate dehydrogenase inhibitors. Journal of Molecular Modeling 2013, 19(3), 1099-1107 doi: 10.1007/s00894-012-1643-5
Marco L. Lolli, Marta M. Giorgis, Paolo P. Tosco, Antonio A Foti, Roberta R. Fruttero and Alberto A. Gasco New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold. Eur J Med Chem 2012, 49, 102-9 doi: 10.1016/j.ejmech.2011.12.038
Giorgis, M.; Lolli, M.L.; Rolando, B.; Rao, A. ; Tosco, P.; Chaurasia, S.; Marabello, D.; Fruttero, R.; Gasco, A.; 1,2,5-Oxadiazole analogues of leflunomide and related compounds. Eur. J. Med Chem. 2011, 46(1), 383-392. doi: 10.1016/j.ejmech.2010.10.029
Lolli, M.L.; Giordano, C.; Pickering, D.S.; Rolando, B.; Hansen, K.B., Foti, A.; Contreras-Sanz, A.; Amir, A.; Fruttero,R.; Gasco,A.; Johansen, T.N. J. Med. Chem. 2010, 53(10), 4110-4118. Tosco P. and Lolli M.L. Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. A computational study on γ-aminobutyric acid (GABA) related compounds. J. Mol. Mod., 2008, 14, 279. https://doi.org/10.1021/jm1001452
Lolli, M. L.; Hansen, S. L.; Rolando, B.; Nielsen, B.; Wellendorph, P.; Madsen, K.; Larsen, O. M.; Kristiansen, U.; Fruttero, R.; Gasco, A.; Johansen, T. N. Hydroxy-1,2,5-oxadiazolyl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Pharmacological Characterization of gamma-Aminobutyric Acid (GABA) Related Compounds. J. Med. Chem., 2006, 49(14), 4442 - 4446 https://doi.org/10.1021/jm051288b